|
KMID : 0613820040140020275
|
|
Journal of Life Science
2004 Volume.14 No. 2 p.275 ~ p.279
|
|
|
Novel Variations in Human Interleukin-29 and Their Association
|
|
Song Ju-Hee
Chae Soo-Cheon
Lee Jae-Hoon
Chung Hun-Taeg
|
|
|
Abstract
|
|
|
|
Gene polymorphisms of cytokines and their receptors are attractive candidates as genetic factors in the pathogenesis of immune-mediated diseases and have been reported to be associated with disease susceptibility to autoimmune, inflammatory and infectious diseases. IL-29 is one of important candidate genes for complex trait of genetic diseases but there is no published survey of single nucleotide polymorphisms (SNPs) in this gene. In this study, for the first time, we have examined the full genomic sequence of IL-29 including the promoter regions to identify SNPs. We examined the frequencies of genotypes and alleles at the SNP site of IL-29 in allergic rhinitis patients and non-allergic rhinitis controls using the direct sequencing method to determine whether this IL-29 SNP is associated with allergic rhinitis in Korean population. We identified one novel SNP (1184C>A) in the intron 2 and one novel variation site (-1842_-1841dupGA) in the promoter region of human IL-29 gene. The P values of SNP or variation site were not significant between the healthy controls and allergic rhinitis patients. Our results suggest that the 1184C>A polymorphism and -1842_-1841dupGA variation site in human IL-29 gene were not associated to allergic rhinitis
|
|
|
KEYWORD
|
|
|
Interukin-29, polymorphisms, Allergic rhinitis, cytokine, variation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|